Computational insights into O-glycosylation in a CTLA4 Fc-fusion protein linker and its impact on protein quality attributes

The hinge region of immunoglobulin G1 (IgG1) is used as a common linker for Fc-fusion therapeutic proteins. With the advances of high-resolution mass spectrometry and sample treatment strategies, unexpected O-linked glycosylation has been observed in the linker. However, the molecular mechanism invo...

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Detalles Bibliográficos
Autores principales: Song, Yuanli, Qian, Yueming, Huang, Zhe, Khattak, Sarwat F., Li, Zheng Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734232/
https://www.ncbi.nlm.nih.gov/pubmed/33335689
http://dx.doi.org/10.1016/j.csbj.2020.11.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734232/
https://www.ncbi.nlm.nih.gov/pubmed/33335689
http://dx.doi.org/10.1016/j.csbj.2020.11.037

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