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Computational insights into O-glycosylation in a CTLA4 Fc-fusion protein linker and its impact on protein quality attributes
The hinge region of immunoglobulin G1 (IgG1) is used as a common linker for Fc-fusion therapeutic proteins. With the advances of high-resolution mass spectrometry and sample treatment strategies, unexpected O-linked glycosylation has been observed in the linker. However, the molecular mechanism invo...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734232/ https://www.ncbi.nlm.nih.gov/pubmed/33335689 http://dx.doi.org/10.1016/j.csbj.2020.11.037 |