Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth

Rab5 is a small GTPase that plays a crucial role in oncogenic signal transduction, which was considered as an attractive target for cancer therapy. Rapid GDP/GTP exchange in the packet of Rab5 sustains its high activity for promoting cancer progression. However, Rab5 currently remains undruggable du...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Sun, Yue, Zhong, Li-Ye, Yu, Nan-Nan, Ouyang, Lan, Fang, Run-Dong, Wang, Yang, He, Qing-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734235/
https://www.ncbi.nlm.nih.gov/pubmed/33335690
http://dx.doi.org/10.1016/j.csbj.2020.11.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734235/
https://www.ncbi.nlm.nih.gov/pubmed/33335690
http://dx.doi.org/10.1016/j.csbj.2020.11.033

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