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Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth
Rab5 is a small GTPase that plays a crucial role in oncogenic signal transduction, which was considered as an attractive target for cancer therapy. Rapid GDP/GTP exchange in the packet of Rab5 sustains its high activity for promoting cancer progression. However, Rab5 currently remains undruggable du...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734235/ https://www.ncbi.nlm.nih.gov/pubmed/33335690 http://dx.doi.org/10.1016/j.csbj.2020.11.033 |