Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells

Recent reports have shown the importance of IFN-γ and T-bet(+) B cells in the pathology of SLE, suggesting the involvement of IFN-γ-producing T-bet(+) CD4(+) cells, i.e., Th1 cells. This study determined the changes in Th1 subsets with metabolic shift and their potential as therapeutic targets in SL...

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Detalles Bibliográficos
Autores principales: Iwata, Shigeru, Zhang, Mingzeng, Hao, He, Trimova, Gulzhan, Hajime, Maiko, Miyazaki, Yusuke, Ohkubo, Naoaki, Satoh Kanda, Yurie, Todoroki, Yasuyuki, Miyata, Hiroko, Ueno, Masanobu, Nagayasu, Atsushi, Nakayamada, Shingo, Sakata, Kei, Tanaka, Yoshiya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734283/
https://www.ncbi.nlm.nih.gov/pubmed/33329581
http://dx.doi.org/10.3389/fimmu.2020.593103

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