Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion

Sestrin2 (Sesn2) is a stress-inducible protein that declines with aging in the heart. We reported that rescue Sesn2 levels in aged mouse hearts through gene therapy improves the resistance of aged hearts to ischemia and reperfusion (I/R) insults. We hypothesize that Sesn2 as a scaffold protein maint...

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Detalles Bibliográficos
Autores principales: Ren, Di, He, Zhibin, Fedorova, Julia, Zhang, Jingwen, Wood, Elizabeth, Zhang, Xiang, Kang, David E., Li, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734306/
https://www.ncbi.nlm.nih.gov/pubmed/33316744
http://dx.doi.org/10.1016/j.redox.2020.101824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734306/
https://www.ncbi.nlm.nih.gov/pubmed/33316744
http://dx.doi.org/10.1016/j.redox.2020.101824

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