Molecular dynamics of the immune checkpoint programmed cell death protein I, PD-1: conformational changes of the BC-loop upon binding of the ligand PD-L1 and the monoclonal antibody nivolumab

BACKGROUND: The immune checkpoint receptor programmed cell death protein I (PD-1) has been identified as a key target in immunotherapy. PD-1 reduces the risk of autoimmunity by inducing apoptosis in antigen-specific T cells upon interaction with programmed cell death protein ligand I (PD-L1). Variou...

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Detalles Bibliográficos
Autores principales: Roither, Bernhard, Oostenbrink, Chris, Schreiner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734776/
https://www.ncbi.nlm.nih.gov/pubmed/33308148
http://dx.doi.org/10.1186/s12859-020-03904-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734776/
https://www.ncbi.nlm.nih.gov/pubmed/33308148
http://dx.doi.org/10.1186/s12859-020-03904-9

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