High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations

BACKGROUND: Children of aged fathers are at a higher risk of developing mental disorders. Alterations in sperm DNA methylation have been implicated as a potential cause. However, age-dependent modifications of the germ cells’ epigenome remain poorly understood. Our objective was to assess the DNA me...

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Detalles Bibliográficos
Autores principales: Cao, Mingju, Shao, Xiaojian, Chan, Peter, Cheung, Warren, Kwan, Tony, Pastinen, Tomi, Robaire, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735420/
https://www.ncbi.nlm.nih.gov/pubmed/33317634
http://dx.doi.org/10.1186/s13148-020-00988-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735420/
https://www.ncbi.nlm.nih.gov/pubmed/33317634
http://dx.doi.org/10.1186/s13148-020-00988-1

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