The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans

Insulin and insulin-like growth factors are longevity determinants that negatively regulate Forkhead box class O (FoxO) transcription factors. In C. elegans mutations that constitutively activate DAF-16, the ortholog of mammalian FoxO3a, extend lifespan by two-fold. While environmental insults induc...

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Detalles Bibliográficos
Autores principales: Rivard, Rebecca S., Morris, Julia M., Youngman, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735605/
https://www.ncbi.nlm.nih.gov/pubmed/33315870
http://dx.doi.org/10.1371/journal.pone.0229812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735605/
https://www.ncbi.nlm.nih.gov/pubmed/33315870
http://dx.doi.org/10.1371/journal.pone.0229812

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