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Long-Range Charge Reorganization as an Allosteric Control Signal in Proteins
[Image: see text] A new mechanism of allostery in proteins, based on charge rather than structure, is reported. We demonstrate that dynamic redistribution of charge within a protein can control its function and affect its interaction with a binding partner. In particular, the association of an antib...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735699/ https://www.ncbi.nlm.nih.gov/pubmed/33211484 http://dx.doi.org/10.1021/jacs.0c10105 |