A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

We establish a murine lung-on-chip infection model and use time-lapse imaging to reveal the dynamics of host-Mycobacterium tuberculosis interactions at an air-liquid interface with a spatiotemporal resolution unattainable in animal models and to probe the direct role of pulmonary surfactant in early...

Descripción completa

Detalles Bibliográficos
Autores principales: Thacker, Vivek V, Dhar, Neeraj, Sharma, Kunal, Barrile, Riccardo, Karalis, Katia, McKinney, John D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735758/
https://www.ncbi.nlm.nih.gov/pubmed/33228849
http://dx.doi.org/10.7554/eLife.59961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735758/
https://www.ncbi.nlm.nih.gov/pubmed/33228849
http://dx.doi.org/10.7554/eLife.59961

Ejemplares similares