Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6C(high) monocytes infiltrate the nerve first and rapidly give way to Ly6C(negative) inflammation-resolving macrophages. In axotomized DRGs,...

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Detalles Bibliográficos
Autores principales: Kalinski, Ashley L, Yoon, Choya, Huffman, Lucas D, Duncker, Patrick C, Kohen, Rafi, Passino, Ryan, Hafner, Hannah, Johnson, Craig, Kawaguchi, Riki, Carbajal, Kevin S, Jara, Juan Sebastian, Hollis, Edmund, Geschwind, Daniel H, Segal, Benjamin M, Giger, Roman J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735761/
https://www.ncbi.nlm.nih.gov/pubmed/33263277
http://dx.doi.org/10.7554/eLife.60223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735761/
https://www.ncbi.nlm.nih.gov/pubmed/33263277
http://dx.doi.org/10.7554/eLife.60223

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