A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

PURPOSE: Tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) activation in Schlemm's canal (SC) endothelium is required for the maintenance of IOP, making the angiopoietin/Tie2 pathway a target for new and potentially disease modifying glaucoma therapies. The goal of the pres...

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Detalles Bibliográficos
Autores principales: Li, Guorong, Nottebaum, Astrid F., Brigell, Mitchell, Navarro, Iris D., Ipe, Ute, Mishra, Sarthak, Gomez-Caraballo, Maria, Schmitt, Heather, Soldo, Brandi, Pakola, Steve, Withers, Barbara, Peters, Kevin G., Vestweber, Dietmar, Stamer, W. Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Physiology and Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735951/
https://www.ncbi.nlm.nih.gov/pubmed/33315051
http://dx.doi.org/10.1167/iovs.61.14.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735951/
https://www.ncbi.nlm.nih.gov/pubmed/33315051
http://dx.doi.org/10.1167/iovs.61.14.12

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