Functional and computational identification of a rescue mutation near the active site of an mRNA methyltransferase

RNA-based drugs are an emerging class of therapeutics combining the immense potential of DNA gene-therapy with the absence of genome integration-associated risks. While the synthesis of such molecules is feasible, large scale in vitro production of humanised mRNA remains a biochemical and economical...

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Detalles Bibliográficos
Autores principales: Colin, Pierre-Yves, Dalby, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736282/
https://www.ncbi.nlm.nih.gov/pubmed/33318548
http://dx.doi.org/10.1038/s41598-020-79026-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736282/
https://www.ncbi.nlm.nih.gov/pubmed/33318548
http://dx.doi.org/10.1038/s41598-020-79026-2

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