Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation

Cisplatin is a commonly used chemotherapy agent with significant dose-limiting neurotoxicity resulting in peripheral neuropathy. Although it is postulated that formation of DNA-platinum adducts is responsible for both its cytotoxicity in cancer cells and side effects in neurons, downstream mechanism...

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Detalles Bibliográficos
Autores principales: Cetinkaya-Fisgin, Aysel, Luan, Xinghua, Reed, Nicole, Jeong, Ye Eun, Oh, Byoung Chol, Hoke, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736304/
https://www.ncbi.nlm.nih.gov/pubmed/33318563
http://dx.doi.org/10.1038/s41598-020-78896-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736304/
https://www.ncbi.nlm.nih.gov/pubmed/33318563
http://dx.doi.org/10.1038/s41598-020-78896-w

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