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In silico derived small molecules targeting the finger-finger interaction between the histone lysine methyltransferase NSD1 and Nizp1 repressor

PHD fingers are small chromatin binding domains, that alone or in tandem work as versatile interaction platforms for diversified activities, ranging from the decoding of the modification status of histone tails to the specific recognition of non-histone proteins. They play a crucial role in their ho...

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Detalles Bibliográficos
Autores principales: Berardi, Andrea, Ghitti, Michela, Quilici, Giacomo, Musco, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736721/
https://www.ncbi.nlm.nih.gov/pubmed/33363704
http://dx.doi.org/10.1016/j.csbj.2020.11.044