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Interstitial telomere sequences disrupt break-induced replication and drive formation of ectopic telomeres
Break-induced replication (BIR) is a mechanism used to heal one-ended DNA double-strand breaks, such as those formed at collapsed replication forks or eroded telomeres. Instead of utilizing a canonical replication fork, BIR is driven by a migrating D-loop and is associated with a high frequency of m...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736798/ https://www.ncbi.nlm.nih.gov/pubmed/33264397 http://dx.doi.org/10.1093/nar/gkaa1081 |