Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations

Ribonucleoprotein (RNP) granules are membraneless organelles (MLOs), which majorly consist of RNA and RNA-binding proteins and are formed via liquid–liquid phase separation (LLPS). Experimental studies investigating the drivers of LLPS have shown that intrinsically disordered proteins (IDPs) and nuc...

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Detalles Bibliográficos
Autores principales: Regy, Roshan Mammen, Dignon, Gregory L, Zheng, Wenwei, Kim, Young C, Mittal, Jeetain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736803/
https://www.ncbi.nlm.nih.gov/pubmed/33264400
http://dx.doi.org/10.1093/nar/gkaa1099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736803/
https://www.ncbi.nlm.nih.gov/pubmed/33264400
http://dx.doi.org/10.1093/nar/gkaa1099

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