Cargando…

Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations

Ribonucleoprotein (RNP) granules are membraneless organelles (MLOs), which majorly consist of RNA and RNA-binding proteins and are formed via liquid–liquid phase separation (LLPS). Experimental studies investigating the drivers of LLPS have shown that intrinsically disordered proteins (IDPs) and nuc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Regy, Roshan Mammen, Dignon, Gregory L, Zheng, Wenwei, Kim, Young C, Mittal, Jeetain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736803/ https://www.ncbi.nlm.nih.gov/pubmed/33264400 http://dx.doi.org/10.1093/nar/gkaa1099

Ejemplares similares

Temperature-Controlled Liquid–Liquid Phase Separation of Disordered Proteins
por: Dignon, Gregory L., et al.
Publicado: (2019)

Sequence determinants of protein phase behavior from a coarse-grained model
por: Dignon, Gregory L., et al.
Publicado: (2018)

TDP-43 α-helical structure tunes liquid–liquid phase separation and function
por: Conicella, Alexander E., et al.
Publicado: (2020)

Molecular interactions underlying liquid-liquid phase separation of the FUS low complexity domain
por: Murthy, Anastasia C., et al.
Publicado: (2019)

Conformation-dependent restraints for polynucleotides: the sugar moiety
por: Kowiel, Marcin, et al.
Publicado: (2020)

How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization
por: Gemeinhardt, Tim M., et al.
Publicado: (2023)

Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
por: Monahan, Zachary, et al.
Publicado: (2017)

Conformation-dependent restraints for polynucleotides: I. Clustering of the geometry of the phosphodiester group
por: Kowiel, Marcin, et al.
Publicado: (2016)

Reversible Kinetic Trapping of FUS Biomolecular Condensates
por: Chatterjee, Sayantan, et al.
Publicado: (2021)

A coarse-grained DNA model to study protein-DNA interactions and liquid-liquid phase separation
por: Kapoor, Utkarsh, et al.
Publicado: (2023)

Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization
por: Phan, Tien M., et al.
Publicado: (2023)

RNA-binding and prion domains: the Yin and Yang of phase separation
por: Gotor, Nieves Lorenzo, et al.
Publicado: (2020)

Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding
por: Her, Cheenou, et al.
Publicado: (2022)

Using symmetry to elucidate the importance of stoichiometry in colloidal crystal assembly
por: Mahynski, Nathan A., et al.
Publicado: (2019)

Shaping the genome via lengthwise compaction, phase separation, and lamina adhesion
por: Brahmachari, Sumitabha, et al.
Publicado: (2022)

Sequence-Dependent Material Properties of Biomolecular Condensates and their Relation to Dilute Phase Conformations
por: Devarajan, Dinesh Sundaravadivelu, et al.
Publicado: (2023)

Enzymes of Polynucleotide Metabolism
por: King, Mary E.
Publicado: (1960)

A multiscale analysis of DNA phase separation: from atomistic to mesoscale level
por: Sun, Tiedong, et al.
Publicado: (2019)

Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation
por: Lin, Chia Liang, et al.
Publicado: (2012)

Balanced Protein–Water Interactions Improve Properties of Disordered Proteins and Non-Specific Protein Association
por: Best, Robert B., et al.
Publicado: (2014)

Correction to Balanced Protein–Water Interactions Improve Properties of Disordered Proteins and Non-Specific Protein Association
por: Best, Robert B., et al.
Publicado: (2015)

Nanoparticulate systems for polynucleotide delivery
por: Basarkar, Ashwin, et al.
Publicado: (2007)

Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search
por: Hemphill, Wayne O., et al.
Publicado: (2023)

A Deep Learning Framework Discovers Compositional Order and Self-Assembly Pathways in Binary Colloidal Mixtures
por: Mao, Runfang, et al.
Publicado: (2022)

Separation and assembly of deep sequencing data into discrete sub-population genomes
por: Karagiannis, Konstantinos, et al.
Publicado: (2017)

Double-Stranded Polynucleotides as Interferon Inducers
por: Field, A. K., et al.
Publicado: (1970)

Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration
por: Ryan, Veronica H, et al.
Publicado: (2020)

Markov state models elucidate the stability of DNA influenced by the chiral 5S-Tg base
por: Wang, Shu-dong, et al.
Publicado: (2022)

Mapping the phase diagram of the writhe of DNA nanocircles using atomistic molecular dynamics simulations
por: Harris, Sarah A., et al.
Publicado: (2008)

Modelling of crowded polymers elucidate effects of double-strand breaks in topological domains of bacterial chromosomes
por: Dorier, Julien, et al.
Publicado: (2013)

ATP dependent NS3 helicase interaction with RNA: insights from molecular simulations
por: Pérez-Villa, Andrea, et al.
Publicado: (2015)

Local combinational variables: an approach used in DNA-binding helix-turn-helix motif prediction with sequence information
por: Xiong, Wenwei, et al.
Publicado: (2009)

Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function
por: Belcastro, Vincenzo, et al.
Publicado: (2011)

SAME-clustering: Single-cell Aggregated Clustering via Mixture Model Ensemble
por: Huh, Ruth, et al.
Publicado: (2020)

Study on Interaction of Cationic Porphyrazine with Synthetic Polynucleotides
por: Dezhampanah, Hamid, et al.
Publicado: (2013)

Novel Aspects of Polynucleotide Phosphorylase Function in Streptomyces
por: Jones, George H.
Publicado: (2018)

Structure and mechanism of Mycobacterium smegmatis polynucleotide phosphorylase
por: Unciuleac, Mihaela-Carmen, et al.
Publicado: (2021)

A Hi–C data-integrated model elucidates E. coli chromosome’s multiscale organization at various replication stages
por: Wasim, Abdul, et al.
Publicado: (2021)

Phase separation in amino acid mixtures is governed by composition
por: De Sancho, David
Publicado: (2022)

Predicting regulatory variants using a dense epigenomic mapped CNN model elucidated the molecular basis of trait-tissue associations
por: Pei, Guangsheng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_idhsaln103erkga4i3rbv4581s