Screening for functional transcriptional and splicing regulatory variants with GenIE

Genome-wide association studies (GWAS) have identified numerous genetic loci underlying human diseases, but a fundamental challenge remains to accurately identify the underlying causal genes and variants. Here, we describe an arrayed CRISPR screening method, Genome engineering-based Interrogation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Cooper, Sarah E, Schwartzentruber, Jeremy, Bello, Erica, Coomber, Eve L, Bassett, Andrew R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736817/
https://www.ncbi.nlm.nih.gov/pubmed/33152068
http://dx.doi.org/10.1093/nar/gkaa960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736817/
https://www.ncbi.nlm.nih.gov/pubmed/33152068
http://dx.doi.org/10.1093/nar/gkaa960

Ejemplares similares