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Screening for functional transcriptional and splicing regulatory variants with GenIE

Genome-wide association studies (GWAS) have identified numerous genetic loci underlying human diseases, but a fundamental challenge remains to accurately identify the underlying causal genes and variants. Here, we describe an arrayed CRISPR screening method, Genome engineering-based Interrogation of...

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Detalles Bibliográficos
Autores principales:	Cooper, Sarah E, Schwartzentruber, Jeremy, Bello, Erica, Coomber, Eve L, Bassett, Andrew R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736817/ https://www.ncbi.nlm.nih.gov/pubmed/33152068 http://dx.doi.org/10.1093/nar/gkaa960

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