Downregulation of PA28α induces proteasome remodeling and results in resistance to proteasome inhibitors in multiple myeloma

Protein homeostasis is critical for maintaining eukaryotic cell function as well as responses to intrinsic and extrinsic stress. The proteasome is a major portion of the proteolytic machinery in mammalian cells and plays an important role in protein homeostasis. Multiple myeloma (MM) is a plasma cel...

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Detalles Bibliográficos
Autores principales: Gu, Yanyan, Barwick, Benjamin G., Shanmugam, Mala, Hofmeister, Craig C., Kaufman, Jonathan, Nooka, Ajay, Gupta, Vikas, Dhodapkar, Madhav, Boise, Lawrence H., Lonial, Sagar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736847/
https://www.ncbi.nlm.nih.gov/pubmed/33318477
http://dx.doi.org/10.1038/s41408-020-00393-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736847/
https://www.ncbi.nlm.nih.gov/pubmed/33318477
http://dx.doi.org/10.1038/s41408-020-00393-0

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