Upregulation of PI3K/AKT/PTEN pathway is correlated with glucose and glutamine metabolic dysfunction during tamoxifen resistance development in MCF-7 cells

Tamoxifen resistance is emerging as a big challenge in endocrine therapy of luminal A breast cancer patients. In this study, we aimed to determine the molecular changes of PI3K/AKT/PTEN signaling pathway during tamoxifen-resistance development using gradually increased doses of tamoxifen in one mode...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamadneh, Lama, Abuarqoub, Rama, Alhusban, Ala, Bahader, Mohamad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736849/
https://www.ncbi.nlm.nih.gov/pubmed/33318536
http://dx.doi.org/10.1038/s41598-020-78833-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736849/
https://www.ncbi.nlm.nih.gov/pubmed/33318536
http://dx.doi.org/10.1038/s41598-020-78833-x

Ejemplares similares