Cargando…

Upregulation of PI3K/AKT/PTEN pathway is correlated with glucose and glutamine metabolic dysfunction during tamoxifen resistance development in MCF-7 cells

Tamoxifen resistance is emerging as a big challenge in endocrine therapy of luminal A breast cancer patients. In this study, we aimed to determine the molecular changes of PI3K/AKT/PTEN signaling pathway during tamoxifen-resistance development using gradually increased doses of tamoxifen in one mode...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamadneh, Lama, Abuarqoub, Rama, Alhusban, Ala, Bahader, Mohamad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736849/ https://www.ncbi.nlm.nih.gov/pubmed/33318536 http://dx.doi.org/10.1038/s41598-020-78833-x

Ejemplares similares

High Performance Liquid Chromatography–Tandem Mass Spectrometry Method for Correlating the Metabolic Changes of Lactate, Pyruvate and L-Glutamine with Induced Tamoxifen Resistant MCF-7 Cell Line Potential Molecular Changes
por: Alhusban, Ala A., et al.
Publicado: (2021)

Changes in Lactate Production, Lactate Dehydrogenase Genes Expression and DNA Methylation in Response to Tamoxifen Resistance Development in MCF-7 Cell Line
por: Hamadneh, Lama, et al.
Publicado: (2021)

Gold Nanocomplex Strongly Modulates the PI3K/Akt Pathway and Other Pathways in MCF-7 Breast Cancer Cell Line
por: Mahmoud, Nouf N., et al.
Publicado: (2020)

Fibronectin expression is upregulated by PI-3K/Akt activation in tamoxifen-resistant breast cancer cells
por: You, Daeun, et al.
Publicado: (2017)

The interaction of the ER with ERBB2 and PI3K results in elevated levels of AKT and p90(RSK )in tamoxifen-resistant MCF-7 cells
por: Pancholi, S, et al.
Publicado: (2005)

Upregulation of NFKBIZ affects bladder cancer progression via the PTEN/PI3K/Akt signaling pathway
por: Xu, Tao, et al.
Publicado: (2021)

Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity
por: Lindberg, Karolina, et al.
Publicado: (2011)

Paired-related homeobox 1 overexpression promotes multidrug resistance via PTEN/PI3K/AKT signaling in MCF-7 breast cancer cells
por: Luo, Haoyue, et al.
Publicado: (2020)

Effects of Combined Pentadecanoic Acid and Tamoxifen Treatment on Tamoxifen Resistance in MCF−7/SC Breast Cancer Cells
por: To, Ngoc Bao, et al.
Publicado: (2022)

Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells
por: Funakoshi-Tago, Megumi, et al.
Publicado: (2020)

Upregulation of SOX11 enhances tamoxifen resistance and promotes epithelial‐to‐mesenchymal transition via slug in MCF‐7 breast cancer cells
por: Xiao, Yingsheng, et al.
Publicado: (2020)

Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
por: Dasari, Venkata Ramesh, et al.
Publicado: (2010)

Epigallocatechin-3-gallate inhibits inflammation and epithelial-mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma
por: Yang, Nan, et al.
Publicado: (2018)

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models
por: Carnero, Amancio, et al.
Publicado: (2014)

Dysregulation of PI3K/Akt/PTEN Pathway in Canine Mammary Tumor
por: Kim, Soo-Hyeon, et al.
Publicado: (2021)

PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice
por: Sun, Chen, et al.
Publicado: (2014)

Simvastatin Evokes An Unpredicted Antagonism For Tamoxifen In MCF-7 Breast Cancer Cells
por: Ibrahim, Amel B, et al.
Publicado: (2019)

The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells
por: Wang, Lijun, et al.
Publicado: (2021)

Hyaluronic acid-coated chitosan nanoparticles as targeted-carrier of tamoxifen against MCF7 and TMX-resistant MCF7 cells
por: Nokhodi, Fariba, et al.
Publicado: (2022)

Retraction: Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
Publicado: (2020)

Cytotoxicity and Cellular Death Modality of Surface-Decorated Gold Nanorods against a Panel of Breast Cancer Cell Lines
por: Abu-Dahab, Rana, et al.
Publicado: (2021)

Tamoxifen and the PI3K Inhibitor: LY294002 Synergistically Induce Apoptosis and Cell Cycle Arrest in Breast Cancer MCF-7 Cells
por: Abdallah, Mohamed E., et al.
Publicado: (2020)

PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
por: Okumura, Naoko, et al.
Publicado: (2012)

Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy
por: Matsuda, Satoru, et al.
Publicado: (2013)

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
por: Lee, Min-Sik, et al.
Publicado: (2015)

BAG5 regulates PTEN stability in MCF-7 cell line
por: Ying, Zhang, et al.
Publicado: (2013)

Reversible control of oestradiol-stimulated growth of MCF-7 tumours by tamoxifen in the athymic mouse.
por: Iino, Y., et al.
Publicado: (1991)

Differential Response to α-Oxoaldehydes in Tamoxifen Resistant MCF-7 Breast Cancer Cells
por: Nass, Norbert, et al.
Publicado: (2014)

Moonlighting Proteins and Cardiopathy in the Spatial Response of MCF‐7 Breast Cancer Cells to Tamoxifen
por: Alkhanjaf, Abdulrab Ahmed M., et al.
Publicado: (2019)

Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing
por: Rouhimoghadam, Milad, et al.
Publicado: (2018)

PI3K/PTEN/AKT Signaling Pathways in Germ Cell Development and Their Involvement in Germ Cell Tumors and Ovarian Dysfunctions
por: De Felici, Massimo, et al.
Publicado: (2021)

Correction: Differential Response to α-Oxoaldehydes in Tamoxifen Resistant MCF-7 Breast Cancer Cells
Publicado: (2014)

Modulation of Tamoxifen Cytotoxicity by Caffeic Acid Phenethyl Ester in MCF-7 Breast Cancer Cells
por: Motawi, Tarek K., et al.
Publicado: (2016)

Nano Packaged Tamoxifen and Curcumin; Effective Formulation against Sensitive and Resistant MCF-7 Cells
por: Hajigholami, Samira, et al.
Publicado: (2018)

TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF-7 cells
por: Zhao, Shuai, et al.
Publicado: (2020)

Synergistic Cytotoxicity between Elephantopus scaber and Tamoxifen on MCF-7-Derived Multicellular Tumor Spheroid
por: Ho, Wan Yong, et al.
Publicado: (2021)

Matrix Stiffness-Upregulated MicroRNA-17-5p Attenuates the Intervention Effects of Metformin on HCC Invasion and Metastasis by Targeting the PTEN/PI3K/Akt Pathway
por: Gao, Xiangyu, et al.
Publicado: (2020)

Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease
por: Matsuda, Satoru, et al.
Publicado: (2013)

Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer’s Disease
por: Matsuda, Satoru, et al.
Publicado: (2018)

Physiological levels of the PTEN-PI3K-AKT axis activity are required for maintenance of Burkitt lymphoma
por: Gehringer, Franziska, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2md8406l91n6qahhqeg481ofbb