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Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss

Age-related hearing loss (AHL) is a progressive sensorineural hearing loss in elderly people. Although no prevention or treatments have been established for AHL, recent studies have demonstrated that oxidative stress is closely related to pathogenesis of AHL, suggesting that suppression of oxidative...

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Detalles Bibliográficos
Autores principales: Oishi, Tetsuya, Matsumaru, Daisuke, Ota, Nao, Kitamura, Hiroshi, Zhang, Tianxiang, Honkura, Yohei, Katori, Yukio, Motohashi, Hozumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736866/
https://www.ncbi.nlm.nih.gov/pubmed/33318486
http://dx.doi.org/10.1038/s41514-020-00053-4