Advances in engineering CRISPR-Cas9 as a molecular Swiss Army knife

The RNA-guided endonuclease system CRISPR-Cas9 has been extensively modified since its discovery, allowing its capabilities to extend far beyond double-stranded cleavage to high fidelity insertions, deletions and single base edits. Such innovations have been possible due to the modular architecture...

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Detalles Bibliográficos
Autores principales: Meaker, Grace A, Hair, Emma J, Gorochowski, Thomas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737000/
https://www.ncbi.nlm.nih.gov/pubmed/33344779
http://dx.doi.org/10.1093/synbio/ysaa021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737000/
https://www.ncbi.nlm.nih.gov/pubmed/33344779
http://dx.doi.org/10.1093/synbio/ysaa021

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