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Advances in engineering CRISPR-Cas9 as a molecular Swiss Army knife
The RNA-guided endonuclease system CRISPR-Cas9 has been extensively modified since its discovery, allowing its capabilities to extend far beyond double-stranded cleavage to high fidelity insertions, deletions and single base edits. Such innovations have been possible due to the modular architecture...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737000/ https://www.ncbi.nlm.nih.gov/pubmed/33344779 http://dx.doi.org/10.1093/synbio/ysaa021 |