Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl(+) cells

BACKGROUND: Resistance to apoptosis in chronic myeloid leukemia (CML) is associated with constitutive tyrosine kinase activity of the Bcr-Abl oncoprotein. The deregulated expression of apoptosis-related genes and alteration in epigenetic machinery may also contribute to apoptosis resistance in CML....

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Detalles Bibliográficos
Autores principales: Burin, Sandra Mara, Cacemiro, Maira da Costa, Cominal, Juçara Gastaldi, Grandis, Rone Aparecido De, Machado, Ana Rita Thomazela, Donaires, Flavia Sacilotto, Cintra, Adelia Cristina Oliveira, Ambrosio, Luciana, Antunes, Lusânia Maria Greggi, Sampaio, Suely Vilela, de Castro, Fabíola Attié
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centro de Estudos de Venenos e Animais Peçonhentos 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737401/
https://www.ncbi.nlm.nih.gov/pubmed/33354202
http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737401/
https://www.ncbi.nlm.nih.gov/pubmed/33354202
http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0123

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