Cargando…

Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl(+) cells

BACKGROUND: Resistance to apoptosis in chronic myeloid leukemia (CML) is associated with constitutive tyrosine kinase activity of the Bcr-Abl oncoprotein. The deregulated expression of apoptosis-related genes and alteration in epigenetic machinery may also contribute to apoptosis resistance in CML....

Descripción completa

Detalles Bibliográficos
Autores principales:	Burin, Sandra Mara, Cacemiro, Maira da Costa, Cominal, Juçara Gastaldi, Grandis, Rone Aparecido De, Machado, Ana Rita Thomazela, Donaires, Flavia Sacilotto, Cintra, Adelia Cristina Oliveira, Ambrosio, Luciana, Antunes, Lusânia Maria Greggi, Sampaio, Suely Vilela, de Castro, Fabíola Attié
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Centro de Estudos de Venenos e Animais Peçonhentos 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737401/ https://www.ncbi.nlm.nih.gov/pubmed/33354202 http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0123

Ejemplares similares

Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells
por: Benati, Rogério Bodini, et al.
Publicado: (2018)

Bothrops moojeni venom and its components – an overview
por: D’Amélio, Fernanda, et al.
Publicado: (2021)

Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines
por: Prinholato da Silva, Cássio, et al.
Publicado: (2015)

Proteopeptidomic, Functional and Immunoreactivity Characterization of Bothrops moojeni Snake Venom: Influence of Snake Gender on Venom Composition
por: Amorim, Fernanda Gobbi, et al.
Publicado: (2018)

New Insights on Moojase, a Thrombin-Like Serine Protease from Bothrops moojeni Snake Venom
por: Amorim, Fernanda G., et al.
Publicado: (2018)

Emerging Role of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Pathogenesis of Haematological Malignancies
por: Cominal, Juçara Gastaldi, et al.
Publicado: (2019)

Comparative compositional and functional analyses of Bothrops moojeni specimens reveal several individual variations
por: Aguiar, Weslei da Silva, et al.
Publicado: (2019)

Bothrops moojeni Venom and Its Components Strongly Affect Osteoclasts’ Maturation and Protein Patterns
por: D’Amélio, Fernanda, et al.
Publicado: (2021)

Bmoo FIBMP-I: A New Fibrinogenolytic Metalloproteinase from Bothrops moojeni Snake Venom
por: Torres, F. S., et al.
Publicado: (2012)

A New Platelet-Aggregation-Inhibiting Factor Isolated from Bothrops moojeni Snake Venom
por: de Sousa, Bruna Barbosa, et al.
Publicado: (2017)

From birth to adulthood: An analysis of the Brazilian lancehead (Bothrops moojeni) venom at different life stages
por: Hatakeyama, Daniela Miki, et al.
Publicado: (2021)

Purification, Characterization and Evaluation of the Antitumoral Activity of a Phospholipase A2 from the Snake Bothrops moojeni
por: Frihling, Breno Emanuel Farias, et al.
Publicado: (2022)

Bothrops moojeni snake venom induces an inflammatory response in preadipocytes: Insights into a new aspect of envenomation
por: Maia-Marques, Rodrigo, et al.
Publicado: (2022)

Rapid Purification of a New P-I Class Metalloproteinase from Bothrops moojeni Venom with Antiplatelet Activity
por: de Queiroz, Mayara R., et al.
Publicado: (2014)

Purification and Characterization of BmooAi: A New Toxin from Bothrops moojeni Snake Venom That Inhibits Platelet Aggregation
por: Ribeiro de Queiroz, Mayara, et al.
Publicado: (2014)

BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells
por: Machado, Ana Rita Thomazela, et al.
Publicado: (2019)

Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism
por: Salvador, Guilherme H. M., et al.
Publicado: (2018)

BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation
por: Bezerra, Patrícia Heloise Alves, et al.
Publicado: (2019)

Analgesic Effect of Photobiomodulation on Bothrops Moojeni Venom-Induced Hyperalgesia: A Mechanism Dependent on Neuronal Inhibition, Cytokines and Kinin Receptors Modulation
por: Nadur-Andrade, Nikele, et al.
Publicado: (2016)

Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A(2) from Bothrops atrox snake venom
por: Menaldo, Danilo L., et al.
Publicado: (2015)

Sulforaphane Combined with Vitamin D Induces Cytotoxicity Mediated by Oxidative Stress, DNA Damage, Autophagy, and JNK/MAPK Pathway Modulation in Human Prostate Tumor Cells
por: Tuttis, Katiuska, et al.
Publicado: (2023)

The Current State-of-the-Art Identification of Unknown Proteins Using Mass Spectrometry Exemplified on De Novo Sequencing of a Venom Protease from Bothrops moojeni
por: König, Simone, et al.
Publicado: (2022)

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I
por: Mian, Afsar Ali, et al.
Publicado: (2012)

Diallyl Disulfide Induces Chemosensitization to Sorafenib, Autophagy, and Cell Cycle Arrest and Inhibits Invasion in Hepatocellular Carcinoma
por: Machado, Ana Rita Thomazela, et al.
Publicado: (2022)

Differential cytokine network profile in polycythemia vera and secondary polycythemia
por: Cacemiro, Maira da Costa, et al.
Publicado: (2020)

Targeting BCR-ABL(+) stem/progenitor cells and BCR-ABL-T315I mutant cells by effective inhibition of the BCR-ABL-Tyr177-GRB2 complex
por: Chen, Min, et al.
Publicado: (2017)

Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
por: Cacemiro, Maira da Costa, et al.
Publicado: (2018)

Erratum on “Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation”
por: Cacemiro, Maira da Costa, et al.
Publicado: (2021)

Bone Marrow Soluble Mediator Signatures of Patients With Philadelphia Chromosome-Negative Myeloproliferative Neoplasms
por: Cominal, Juçara Gastaldi, et al.
Publicado: (2021)

BCR/ABL1 and BCR are under the transcriptional control of the MYC oncogene
por: Sharma, Nitesh, et al.
Publicado: (2015)

Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells
por: Kawakami, Shohei, et al.
Publicado: (2022)

Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
por: Ayres, Lorena Rocha, et al.
Publicado: (2015)

BCR: a new target in resistance mediated by BCR/ABL-315I?
por: Haberbosch, Isabella, et al.
Publicado: (2016)

Treatment with a Zinc Metalloprotease Purified from Bothrops moojeni Snake Venom (BmooMP-Alpha-I) Reduces the Inflammation in an Experimental Model of Dextran Sulfate Sodium-Induced Colitis
por: Silva, Maraisa Cristina, et al.
Publicado: (2019)

The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins
por: You, Liangshun, et al.
Publicado: (2016)

Expanding the Diversity of Allosteric Bcr-Abl Inhibitors
por: Deng, Xianming, et al.
Publicado: (2010)

An In-House Method for Molecular Monitoring of BCR-ABL
por: Sercan, Hakkı Ogün, et al.
Publicado: (2012)

Depression of oncogenecity by dephosphorylating and degrading BCR-ABL
por: Gao, Miao, et al.
Publicado: (2016)

Caffeic acid and chlorogenic acid cytotoxicity, genotoxicity and impact on global DNA methylation in human leukemic cell lines
por: Hernandes, Lívia Cristina, et al.
Publicado: (2020)

AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells
por: Zhou, Liang L., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_acgt5ff92n4bc3akr9pn5rhn5a