Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Autophagosome formation requires multiple autophagy‐related (ATG) factors. However, we find that a subset of autophagy substrates remains robustly targeted to the lysosome in the absence of several core ATGs, including the LC3 lipidation machinery. To address this unexpected result, we performed gen...

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Detalles Bibliográficos
Autores principales: Ohnstad, Amelia E, Delgado, Jose M, North, Brian J, Nasa, Isha, Kettenbach, Arminja N, Schultz, Sebastian W, Shoemaker, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737610/
https://www.ncbi.nlm.nih.gov/pubmed/33226137
http://dx.doi.org/10.15252/embj.2020104948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737610/
https://www.ncbi.nlm.nih.gov/pubmed/33226137
http://dx.doi.org/10.15252/embj.2020104948

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