Non-catalytic-Region Mutations Conferring Transition of Class A β-Lactamases Into ESBLs

Despite class A ESBLs carrying substitutions outside catalytic regions, such as Cys69Tyr or Asn136Asp, have emerged as new clinical threats, the molecular mechanisms underlying their acquired antibiotics-hydrolytic activity remains unclear. We discovered that this non-catalytic-region (NCR) mutation...

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Detalles Bibliográficos
Autores principales: Cao, Thinh-Phat, Yi, Hyojeong, Dhanasingh, Immanuel, Ghosh, Suparna, Choi, Jin Myung, Lee, Kun Ho, Ryu, Seol, Kim, Heenam Stanley, Lee, Sung Haeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737660/
https://www.ncbi.nlm.nih.gov/pubmed/33335913
http://dx.doi.org/10.3389/fmolb.2020.598998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737660/
https://www.ncbi.nlm.nih.gov/pubmed/33335913
http://dx.doi.org/10.3389/fmolb.2020.598998

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