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Non-catalytic-Region Mutations Conferring Transition of Class A β-Lactamases Into ESBLs
Despite class A ESBLs carrying substitutions outside catalytic regions, such as Cys69Tyr or Asn136Asp, have emerged as new clinical threats, the molecular mechanisms underlying their acquired antibiotics-hydrolytic activity remains unclear. We discovered that this non-catalytic-region (NCR) mutation...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737660/ https://www.ncbi.nlm.nih.gov/pubmed/33335913 http://dx.doi.org/10.3389/fmolb.2020.598998 |