Integrating comprehensive functional annotations to boost power and accuracy in gene-based association analysis

Gene-based association tests aggregate genotypes across multiple variants for each gene, providing an interpretable gene-level analysis framework for genome-wide association studies (GWAS). Early gene-based test applications often focused on rare coding variants; a more recent wave of gene-based met...

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Detalles Bibliográficos
Autores principales: Quick, Corbin, Wen, Xiaoquan, Abecasis, Gonçalo, Boehnke, Michael, Kang, Hyun Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737906/
https://www.ncbi.nlm.nih.gov/pubmed/33320851
http://dx.doi.org/10.1371/journal.pgen.1009060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737906/
https://www.ncbi.nlm.nih.gov/pubmed/33320851
http://dx.doi.org/10.1371/journal.pgen.1009060

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