Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis

Genomic dissection of antibiotic resistance in bacterial pathogens has largely focused on genetic changes conferring growth above a single critical concentration of drug. However, reduced susceptibility to antibiotics—even below this breakpoint—is associated with poor treatment outcomes in the clini...

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Detalles Bibliográficos
Autores principales: Hicks, Nathan D., Giffen, Samantha R., Culviner, Peter H., Chao, Michael C., Dulberger, Charles L., Liu, Qingyun, Stanley, Sydney, Brown, Jessica, Sixsmith, Jaimie, Wolf, Ian D., Fortune, Sarah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738170/
https://www.ncbi.nlm.nih.gov/pubmed/33253310
http://dx.doi.org/10.1371/journal.ppat.1009063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738170/
https://www.ncbi.nlm.nih.gov/pubmed/33253310
http://dx.doi.org/10.1371/journal.ppat.1009063

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