Cargando…
Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis
Genomic dissection of antibiotic resistance in bacterial pathogens has largely focused on genetic changes conferring growth above a single critical concentration of drug. However, reduced susceptibility to antibiotics—even below this breakpoint—is associated with poor treatment outcomes in the clini...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738170/ https://www.ncbi.nlm.nih.gov/pubmed/33253310 http://dx.doi.org/10.1371/journal.ppat.1009063 |