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Accurate prediction of kinase-substrate networks using knowledge graphs

Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular processes. However, discovering specific kinase-substrate relationships is time-consuming and often rather serendipitous. Computational predictions alleviate these ch...

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Detalles Bibliográficos
Autores principales: Nováček, Vít, McGauran, Gavin, Matallanas, David, Vallejo Blanco, Adrián, Conca, Piero, Muñoz, Emir, Costabello, Luca, Kanakaraj, Kamalesh, Nawaz, Zeeshan, Walsh, Brian, Mohamed, Sameh K., Vandenbussche, Pierre-Yves, Ryan, Colm J., Kolch, Walter, Fey, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738173/
https://www.ncbi.nlm.nih.gov/pubmed/33270624
http://dx.doi.org/10.1371/journal.pcbi.1007578