Cargando…

Accurate prediction of kinase-substrate networks using knowledge graphs

Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular processes. However, discovering specific kinase-substrate relationships is time-consuming and often rather serendipitous. Computational predictions alleviate these ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nováček, Vít, McGauran, Gavin, Matallanas, David, Vallejo Blanco, Adrián, Conca, Piero, Muñoz, Emir, Costabello, Luca, Kanakaraj, Kamalesh, Nawaz, Zeeshan, Walsh, Brian, Mohamed, Sameh K., Vandenbussche, Pierre-Yves, Ryan, Colm J., Kolch, Walter, Fey, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738173/ https://www.ncbi.nlm.nih.gov/pubmed/33270624 http://dx.doi.org/10.1371/journal.pcbi.1007578

Ejemplares similares

Centralised Full Access to Clinical Study Data Can Support Unbiased Guideline Development, Continuing Medical Education, and Patient Information
por: McGauran, Natalie, et al.
Publicado: (2021)

From publication bias to lost in information: why we need a central public portal for clinical trial data
por: Wieseler, Beate, et al.
Publicado: (2022)

Disagreement in primary study selection between systematic reviews on negative pressure wound therapy
por: Peinemann, Frank, et al.
Publicado: (2008)

Negative pressure wound therapy: Potential publication bias caused by lack of access to unpublished study results data
por: Peinemann, Frank, et al.
Publicado: (2008)

All over the place: deciphering HRAS signaling from different subcellular compartments
por: Kolch, Walter, et al.
Publicado: (2019)

Access to regulatory data from the European Medicines Agency: the times they are a-changing
por: Wieseler, Beate, et al.
Publicado: (2012)

The Ins and Outs of RAS Effector Complexes
por: Kiel, Christina, et al.
Publicado: (2021)

A systematic comparison of different composite measures (DAS 28, CDAI, SDAI, and Boolean approach) for determining treatment effects on low disease activity and remission in rheumatoid arthritis
por: Janke, Kirsten, et al.
Publicado: (2022)

Reporting bias in medical research - a narrative review
por: McGauran, Natalie, et al.
Publicado: (2010)

Impact of Inclusion of Industry Trial Results Registries as an Information Source for Systematic Reviews
por: Potthast, Regine, et al.
Publicado: (2014)

Poroid hidradenocarcinoma and atypical hidradenoma papilliferum of the vulva – Two cases
por: McGauran, Monica F.G., et al.
Publicado: (2021)

Results on patient-reported outcomes are underreported in summaries of product characteristics for new drugs
por: Haag, Susanne, et al.
Publicado: (2021)

Personalized Computational Models as Biomarkers
por: Kolch, Walter, et al.
Publicado: (2017)

Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer’s Disease?
por: Dunning, Christopher J., et al.
Publicado: (2015)

Guideline appraisal with AGREE II: online survey of the potential influence of AGREE II items on overall assessment of guideline quality and recommendation for use
por: Hoffmann-Eßer, Wiebke, et al.
Publicado: (2018)

RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy
por: García-Gutiérrez, Lucía, et al.
Publicado: (2020)

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling
por: Nolan, Aoife A., et al.
Publicado: (2021)

Completeness of Reporting of Patient-Relevant Clinical Trial Outcomes: Comparison of Unpublished Clinical Study Reports with Publicly Available Data
por: Wieseler, Beate, et al.
Publicado: (2013)

Subvoxel Accurate Graph Search Using Non-Euclidean Graph Space
por: Abràmoff, Michael D., et al.
Publicado: (2014)

An Artificial Intelligence-Based Tool for Data Analysis and Prognosis in Cancer Patients: Results from the Clarify Study
por: Torrente, María, et al.
Publicado: (2022)

Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device
por: Nguyen, Lan K, et al.
Publicado: (2015)

Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib
por: Nolan, Aoife, et al.
Publicado: (2023)

BAX and SMAC regulate bistable properties of the apoptotic caspase system
por: McKenna, Stephanie, et al.
Publicado: (2021)

Accurate Indoor Localization Based on CSI and Visibility Graph
por: Wu, Zhefu, et al.
Publicado: (2018)

Indexed variation graphs for efficient and accurate resistome profiling
por: Rowe, Will P M, et al.
Publicado: (2018)

Frailty Screening in the Emergency Department: Comparing the Variable Indicative of Placement Risk, Clinical Frailty Scale and PRISMA-7
por: O’Caoimh, Rónán, et al.
Publicado: (2022)

Accurate assembly of transcripts through phase-preserving graph decomposition
por: Shao, Mingfu, et al.
Publicado: (2017)

Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades
por: Fey, Dirk, et al.
Publicado: (2012)

Information on new drugs at market entry: retrospective analysis of health technology assessment reports versus regulatory reports, journal publications, and registry reports
por: Köhler, Michael, et al.
Publicado: (2015)

Accurate HLA type inference using a weighted similarity graph
por: Xie, Minzhu, et al.
Publicado: (2010)

Fast and Accurate Prediction of Refractive Index of Organic Liquids with Graph Machines
por: Duprat, François, et al.
Publicado: (2023)

Chaining for accurate alignment of erroneous long reads to acyclic variation graphs
por: Ma, Jun, et al.
Publicado: (2023)

Accurate and fast graph-based pangenome annotation and clustering with ggCaller
por: Horsfield, Samuel T., et al.
Publicado: (2023)

Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma
por: Romano, David, et al.
Publicado: (2022)

SKIMMR: facilitating knowledge discovery in life sciences by machine-aided skim reading
por: Nováček, Vít, et al.
Publicado: (2014)

BrownieAligner: accurate alignment of Illumina sequencing data to de Bruijn graphs
por: Heydari, Mahdi, et al.
Publicado: (2018)

Accurate sequence variant genotyping in cattle using variation-aware genome graphs
por: Crysnanto, Danang, et al.
Publicado: (2019)

Accurate self-correction of errors in long reads using de Bruijn graphs
por: Salmela, Leena, et al.
Publicado: (2017)

Fast and Accurate Lane Detection via Graph Structure and Disentangled Representation Learning
por: He, Yulin, et al.
Publicado: (2021)

A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events
por: Ryan, Colm J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pl4kq3atpbm5jqjsajs99j89jl