Cargando…
Temperature dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome
The SARS-CoV-2 virus and its homolog SARS-CoV penetrate human cells by binding of viral spike protein and human angiotensin converting enzyme II (ACE2). SARS-CoV causes high fever in almost all patients, while SARS-CoV-2 does not. Moreover, analysis of the clinical data revealed that the higher body...
Autores principales: | Zhou, Zhonghua, Yang, Ziyi, Ou, Junxian, Zhang, Hong, Zhang, Qiwei, Dong, Ming, Zhang, Gong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738279/ https://www.ncbi.nlm.nih.gov/pubmed/33343834 http://dx.doi.org/10.1016/j.csbj.2020.12.005 |
Ejemplares similares
-
V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity
por: Ou, Junxian, et al.
Publicado: (2021) -
Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2
por: Prévost, Jérémie, et al.
Publicado: (2021) -
Structural insights into the Omicron spike trimer: tackling the challenges of continuously evolving SARS-CoV-2 variants
por: Ou, Junxian, et al.
Publicado: (2022) -
Mechanistic Origin of Different Binding Affinities of SARS-CoV and SARS-CoV-2 Spike RBDs to Human ACE2
por: Zhang, Zhi-Bi, et al.
Publicado: (2022) -
Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein
por: Calcagnile, Matteo, et al.
Publicado: (2021)