Discovery of orally active chalcones as histone lysine specific demethylase 1 inhibitors for the treatment of leukaemia

Histone lysine specific demethylase 1 (LSD1) has emerged as an attractive molecule target for the discovery of potently anticancer drugs to treat leukaemia. In this study, a series of novel chalcone derivatives were designed, synthesised and evaluated for their inhibitory activities against LSD1 in ...

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Detalles Bibliográficos
Autores principales: Li, Yang, Sun, Ying, Zhou, Yang, Li, Xinyang, Zhang, Huan, Zhang, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738283/
https://www.ncbi.nlm.nih.gov/pubmed/33307878
http://dx.doi.org/10.1080/14756366.2020.1852556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738283/
https://www.ncbi.nlm.nih.gov/pubmed/33307878
http://dx.doi.org/10.1080/14756366.2020.1852556

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