The Q336H MAPT Mutation Linked to Pick’s Disease Leads to Increased Binding of Tau to the Microtubule Network via Altered Conformational and Phosphorylation Effects

Tauopathies are neurodegenerative disorders characterized by Tau aggregation. Genetic studies on familial cases allowed for the discovery of mutations in the MAPT gene that increase Tau propensity to detach from microtubules and to form insoluble cytoplasmic Tau aggregates. Recently, the rare mutati...

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Detalles Bibliográficos
Autores principales: Siano, Giacomo, Micaelli, Mariachiara, Scarlatti, Arianna, Quercioli, Valentina, Di Primio, Cristina, Cattaneo, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738341/
https://www.ncbi.nlm.nih.gov/pubmed/33343296
http://dx.doi.org/10.3389/fnmol.2020.569395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738341/
https://www.ncbi.nlm.nih.gov/pubmed/33343296
http://dx.doi.org/10.3389/fnmol.2020.569395

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