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A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Snakebite is a medical emergency causing high mortality and morbidity in rural tropical communities that typically experience delayed access to unaffordable therapeutics. Viperid snakes are responsible for the majority of envenomings, but extensive interspecific variation in venom composition dictat...

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Detalles Bibliográficos
Autores principales: Albulescu, Laura-Oana, Xie, Chunfang, Ainsworth, Stuart, Alsolaiss, Jaffer, Crittenden, Edouard, Dawson, Charlotte A., Softley, Rowan, Bartlett, Keirah E., Harrison, Robert A., Kool, Jeroen, Casewell, Nicholas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738508/
https://www.ncbi.nlm.nih.gov/pubmed/33323937
http://dx.doi.org/10.1038/s41467-020-19981-6