T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice

IL-2Rα, in part, comprises the high affinity receptor for IL-2, a cytokine important in immune proliferation, activation, and regulation. IL-2Rα deficient mice (IL-2Rα-KO) develop systemic autoimmune disease and die from severe anemia between 18 and 80 days of age. These mice develop kinetically dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Mullins, Genevieve N., Valentine, Kristen M., Al-Kuhlani, Mufadhal, Davini, Dan, Jensen, Kirk D. C., Hoyer, Katrina K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738527/
https://www.ncbi.nlm.nih.gov/pubmed/33319815
http://dx.doi.org/10.1038/s41598-020-78975-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738527/
https://www.ncbi.nlm.nih.gov/pubmed/33319815
http://dx.doi.org/10.1038/s41598-020-78975-y

Ejemplares similares