Cargando…
T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice
IL-2Rα, in part, comprises the high affinity receptor for IL-2, a cytokine important in immune proliferation, activation, and regulation. IL-2Rα deficient mice (IL-2Rα-KO) develop systemic autoimmune disease and die from severe anemia between 18 and 80 days of age. These mice develop kinetically dis...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738527/ https://www.ncbi.nlm.nih.gov/pubmed/33319815 http://dx.doi.org/10.1038/s41598-020-78975-y |