Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain

Background: Aggregation of the amyloid-beta (Aβ) peptide is one of the main neuropathological events in Alzheimer's disease (AD). Neprilysin is the major enzyme degrading Aβ, with its activity enhanced by the neuropeptide somatostatin (SST). SST levels are decreased in the brains of AD patients...

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Detalles Bibliográficos
Autores principales: Rofo, Fadi, Ugur Yilmaz, Canan, Metzendorf, Nicole, Gustavsson, Tobias, Beretta, Chiara, Erlandsson, Anna, Sehlin, Dag, Syvänen, Stina, Nilsson, Per, Hultqvist, Greta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738863/
https://www.ncbi.nlm.nih.gov/pubmed/33391505
http://dx.doi.org/10.7150/thno.50263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738863/
https://www.ncbi.nlm.nih.gov/pubmed/33391505
http://dx.doi.org/10.7150/thno.50263

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