Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders

Severe stress exposure causes the loss of dendritic spines on cortical pyramidal neurons and induces psychiatric-like symptoms in rodent models. These effects are strongest following early-life stress and are most persistent on apical dendrites. However, the long-term impacts and temporal effects of...

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Detalles Bibliográficos
Autores principales: Kaul, Dominic, Smith, Caine C., Stevens, Julia, Fröhlich, Anna S., Binder, Elisabeth B., Mechawar, Naguib, Schwab, Sibylle G., Matosin, Natalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739192/
https://www.ncbi.nlm.nih.gov/pubmed/33344723
http://dx.doi.org/10.1016/j.ynstr.2020.100270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739192/
https://www.ncbi.nlm.nih.gov/pubmed/33344723
http://dx.doi.org/10.1016/j.ynstr.2020.100270

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