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Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders
Severe stress exposure causes the loss of dendritic spines on cortical pyramidal neurons and induces psychiatric-like symptoms in rodent models. These effects are strongest following early-life stress and are most persistent on apical dendrites. However, the long-term impacts and temporal effects of...
Autores principales: | Kaul, Dominic, Smith, Caine C., Stevens, Julia, Fröhlich, Anna S., Binder, Elisabeth B., Mechawar, Naguib, Schwab, Sibylle G., Matosin, Natalie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739192/ https://www.ncbi.nlm.nih.gov/pubmed/33344723 http://dx.doi.org/10.1016/j.ynstr.2020.100270 |
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