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Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders
Severe stress exposure causes the loss of dendritic spines on cortical pyramidal neurons and induces psychiatric-like symptoms in rodent models. These effects are strongest following early-life stress and are most persistent on apical dendrites. However, the long-term impacts and temporal effects of...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739192/ https://www.ncbi.nlm.nih.gov/pubmed/33344723 http://dx.doi.org/10.1016/j.ynstr.2020.100270 |