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Reduction of Dendritic Inhibition in CA1 Pyramidal Neurons in Amyloidosis Models of Early Alzheimer’s Disease

BACKGROUND: In an early stage of Alzheimer’s disease (AD), before the formation of amyloid plaques, neuronal network hyperactivity has been reported in both patients and animal models. This suggests an underlying disturbance of the balance between excitation and inhibition. Several studies have high...

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Detalles Bibliográficos
Autores principales: Ruiter, Marvin, Herstel, Lotte J., Wierenga, Corette J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739974/
https://www.ncbi.nlm.nih.gov/pubmed/33074225
http://dx.doi.org/10.3233/JAD-200527