Longevity-Extending MetAP2 Inhibitors Induce Caloric Restriction Through P53-Dependent Induction of GDF-15

MetAP2 is a 67kDa protein which sits at the translation initiation complex and cleaves N-terminal methionine off of nascent peptides. Inhibitors of MetAP2 cause profound weight loss secondary to decreased food intake. These inhibitors also significantly extend longevity in mice in late-life interven...

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Detalles Bibliográficos
Autores principales: MacArthur, Michael, Mitchell, Sarah, Jung, Jon, Torrence, Margaret, Kane, Alice, Mehmet, Huseyin, Manning, Brendan, Mitchell, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741419/
http://dx.doi.org/10.1093/geroni/igaa057.413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7741419/
http://dx.doi.org/10.1093/geroni/igaa057.413

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