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Piece-wise linear models of biological systems—Application, analysis, and comparison with nonlinear models using the example of the p53 regulatory module
In this paper, we propose to use a linear system with switching methodology for description and analysis of complex biological systems. We show advantages of the proposed approach over the one usually used, which is based on ODE. We propose the detailed methodology of a full analysis of developed mo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743982/ https://www.ncbi.nlm.nih.gov/pubmed/33326446 http://dx.doi.org/10.1371/journal.pone.0243823 |