Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial

INTRODUCTION: Allopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well‐established preclinical safety efficacy make it a viable candidate. METHODS: A randomized, doubl...

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Detalles Bibliográficos
Autores principales: Hernandez, Gerson D., Solinsky, Christine M., Mack, Wendy J., Kono, Naoko, Rodgers, Kathleen E., Wu, Chun‐Yi, Mollo, Ana R., Lopez, Claudia M., Pawluczyk, Sonia, Bauer, Gerhard, Matthews, Dawn, Shi, Yonggang, Law, Meng, Rogawski, Michael A., Schneider, Lon S., Brinton, Roberta D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744018/
https://www.ncbi.nlm.nih.gov/pubmed/33344752
http://dx.doi.org/10.1002/trc2.12107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744018/
https://www.ncbi.nlm.nih.gov/pubmed/33344752
http://dx.doi.org/10.1002/trc2.12107

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